Spontaneous Heart Failure in BALB/c Mice
نویسندگان
چکیده
منابع مشابه
Congestive heart failure in copper-deficient mice.
Copper Deficiency (CuD) leads to hypertrophic cardiomyopathy in various experimental models. The morphological, electrophysiological, and molecular aspects of this hypertrophy have been under investigation for a long time. However the transition from compensated hypertrophy to decompensated heart failure has not been investigated in the study of CuD. We set out to investigate the contractile an...
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• The dog has been widely used in experimental procedures designed to approximate congestive failure of the circulatory system. It is not generally realized that many dogs are affected by spontaneous heart disease that resembles human congestive failure and other forms of human heart disease. Although the life span of dogs is relatively short in comparison to that of man, the more rapid aging p...
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Sarcomeres, bundled into thick and thin filaments, are the units of contraction in the striated muscle. The thick filaments comprise several hundred hexameric myosin molecules, composed of 2 myosin heavy chain (MyHC) proteins, the molecular motor of contraction, and 2 regulatory and 2 essential light chains. The globular head of MyHC contains the binding domains for cardiac -actin and adenosine...
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Background—Hydrogen sulfide (H 2 S) is an endogenous signaling molecule with potent cytoprotective effects. The present study evaluated the therapeutic potential of H 2 S in murine models of heart failure. Methods and Results—Heart failure was induced by subjecting mice either to permanent ligation of the left coronary artery for 4 weeks or to 60 minutes of left coronary artery occlusion follow...
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ژورنال
عنوان ژورنال: Experimental Animals
سال: 1988
ISSN: 0007-5124,1881-7122
DOI: 10.1538/expanim1978.37.2_121